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Universitätsklinikum Essen
Direkteinstieg:
Studien & Forschung

Publications

Selected publications

 

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S. (2017)

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017 Mar 16;8:14600

 

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun. 2017 Mar 1;8:14447. 

 

Klose R, Krzywinska E, Castells M, Gotthardt D, Putz EM, Kantari-Mimoun C, Chikdene N, Meinecke AK, Schrödter K, Helfrich I, Fandrey J, Sexl V, Stockmann C.

Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun 2016 7:12528. 

 

Stoffels I, Morscher S, Helfrich I, Hillen U, Lehy J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J

Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 2015 7: 317 

 

Ullrich N, Löffek S, Horn S, Ennen M, Sánchez-Del-Campo L, Zhao F, Breitenbuecher F, Davidson I, Singer BB, Schadendorf D, Goding CR, Helfrich I. (2015):

MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma. Pigment Cell Melanoma Res. 2015 Aug 24

 

Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. (2015):

Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med. 2015 Apr 7;7(6):714-34.

 

Ullrich N, Heinemann A, Nilewski E, Scheffrahn I, Klode J, Scherag A, Schadendorf D, Singer BB, Helfrich I. (2015):

CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival. Cancer Res. 2015 May 1;75(9):1897-907. 

 

Bald T, Quast T, [ ], Helfrich I et. al., (2014):

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature. 2014 Mar 6;507(7490):109-13

 

Helfrich I, Ullrich N, Zigrino P, Schadendorf D (2014):

Primary tumor versus metastasis: new experimental models for studies on cancer cell homing and metastasis in melanoma. Pigment Cell Melanoma Res. 2014 Mar;27(2):309-16

 

Hansen, W., Hutzler, M., Abel, S., Alter, C., Stockmann, C., Kliche, S., Albert, J., Sparwasser, T., Sakaguchi, S., Westendorf, A.M., Schadendorf, D., Buer, J.*, Helfrich, I.* (2012).

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med. 2012 Oct 22;209(11):2001-16 *authors are contributed equally to this work

 

Helfrich, I. and Schadendorf, D (2011):

Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti-angiogenic drug resistance? Mol Oncol. 2011 Apr;5(2):137-49

 

Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, Nasarre P, Hofer-Warbinek R, Bilban M, Augustin HG, Hofer E (2011):

The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood 2011 Mar 3;117(9):2735-44.

 

Helfrich, I., Scheffrahn, I., Bartling, S., von Felbert, V., Weis, J., Middleton, M., Kato, M., Ergün, S., Schadendorf, D. (2010):

Resistance to anti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma. J Exp Med  2010 Mar 15;07(3):491-503.

 

Helfrich, I., Edler, L., Sucker, A., Thomas, M., Schadendorf, D., Augustin, H.G. (2009):

Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res. 2009 Feb 15;15(4):1384-92.

 

Helfrich I, Schmitz A, Zigrino P, Michels C, Haase I, le Bivic A, Leitges M, Niessen CM (2007):

Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol. 2007 Apr;127(4):742-4

 

Tunggal JA*, Helfrich I*, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005):

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005 March; 24(6):1146-56 *authors are contributed equally to this work

 

I. Helfrich, M. Chen, R. Schmidt, A. Kopp-Schneider, H.J. Gröne, G. Fürstenberger, F. Rösl and H. zur Hausen (2004):

Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis. J Virol. 2004 May; 78(9):4797-805.