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Universitätsklinikum Essen
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Zentrale Terminkoordination

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Studien & Forschung

Publications

 

https://pubmed.ncbi.nlm.nih.gov/?term=alpaslan+tasdogan&sort=date

Aurora AB, Khivansara V, Leach A, Gill JG, Martin-Sandoval M, Yang C, Kasitinon SY, Bezwada D, Tasdogan A, Gu W, Mathews TP, Zhao Z, DeBerardinis RJ, Morrison SJ. (2022). Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells. Proc Natl Acad Sci U S A, Feb 8;119(6):e2120617119.

 

Tasdogan A*, Faubert B*, Morrison SJ, Mathews TP, DeBerardinis RJ. (2021). Stable isotope tracing to assess tumor metabolism in vivo. Nature Protocols, 16(11):5123-5145, *contributed equally to this work

 

Zhang J, Cohen A, Shen B, Du L, Tasdogan A, Zhao Z, Shane EJ, Morrison SJ. (2021). The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin. PNAS, 22;118(25):e2026176118.

 

Shen B, Tasdogan A, Ubelacker JM, Zhang J, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Hu Z, Zhao Z, Crane CM, Morrison SJ. (2021). A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature. 591(7850):438-444.

 

DeVilbiss AW, Zhao Z, Martin-Sandoval MS, Ubellacker JM, Tasdogan A, Agathocleous M,Mathews TP, Morrison SJ. (2021). Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues. eLife, 20;10:e61980.

 

Johnston K, Pachnis P, Tasdogan A, Faubert B, Vu D, Zacharias LG, Mathews TP, Ricciardio S, Johnson A, Rodgers-Augustyniak L, Zhao Z, Leavey P, Watt T, DeBerardinis RJ. (2021). Intra-operative isotope tracing in multiple pediatric solid tumors demonstrate broad utilization of oxidative metabolism. Cell MED, 9;2(4):395-410.

 

Schmid T, Maier J, Martin M, Tasdogan A, Tausch E, Barth TFE, Stilgenbauer S, Bloehdorn J, Möller P, Mellert K. (2020) U-RT1 - A new model for Richter transformation. Neoplasia. 11;23(1):140-148

 

Ubelacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, Zhimin Gu, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews T, Morrison SJ. (2020). Lymph protects metastasizing melanoma cells from ferroptosis. Nature 585:113-118.

 

Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A. Murphy MM, Gu W, Martin M, Mathews TP, Vandergriff T, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ. (2020). Metabolic heterogeneity among melanoma cells confers differences in metastatic potential. Nature 577:115-120

 

Kasitinon SY, Eskiocak U, Martin M, Bezwada D, Khivansara V, Tasdogan A, Zhao Z, Mathews T, Aurora AB, Morrison SJ. (2019). TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling. Cell Reports 28:2293-2305

 

Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J. (2019). Loss of EZH2 Activates BCAA Metabolism to Drive Leukemic Transformation. Cancer Discovery 9:1228-1247

 

Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Crane G, Morrison SJ. (2019). Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. eLife e42274

 

Shi X, Tasdogan A, Huang F, Hu Z, Morrison SJ, DeBerardinis RJ. (2017). The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts. Science Advances 3:eaao5268

 

Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth BM, Slany R, Fehling HJ, Kranz A, Stewart AF, Anastassiadis K. (2018). The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. eLife e27157

 

Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B. (2018). NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS. EMBO J 37.pii: e98697

 

Lee S, Liu P, Tschaffon M, Knoll J, Tasdogan A, Witting R, Frappart L, Bertolino P, Zhang C, Tuckermann J. (2018). A genetic benign jaw tumor mouse model by loss of menin in the osteoblast lineage in mice. Oncogene 37:616-626

 

Kraus LF, Scheurmann N, Frenzel DF, Tasdogan A, Weiss JM. (2018). 9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy. Contact Dermatitis 78:41-54

 

Herzig J, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, Rücker F, Paschka P, Dolnik A, Schneider E, Kuchenbauer F, Heidel F, Buske C, Döhner H, Döhner K, Gaidzik V. (2017). Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair. Oncotarget 8:95038-95053

 

Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M. (2017). Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nature Communications 8:15746

 

Tauc HM, Tasdogan A, Meyer P, Pandur P. (2017). Nipped-A regulates intestinal stem cell proliferation in Drosophila. Development 144:612-623

 

Gentner E, Vegi NM, Mulaw MA, Mandal T, Bamezai S, Claus R, Tasdogan A, Quintanilla-Martinez L, Grunenberg A, Döhner K, Döhner H, Bullinger L, Haferlach T, Buske C, Rawat VP, Feuring-Buske M. (2016). VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice. Oncotarget 7:86889-86901

 

Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, Mulaw M, Madan V, Scharffetter-Kochanek K, Feuring-Buske M, Doehner K, Speit G, Stewart AF, Fehling HJ. (2016). DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization. Cell Stem Cell 19:752-767

 

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP. (2015). Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nature Communications 6:7796

 

Mühl B*, Hägele J*, Tasdogan A*, Loula P, Schuh K, Bundschu K. (2015). SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells. Developmental Dynamics 244:591-606 *contributed equally to this work

 

Gatzka M, Tasdogan A, Hainzl A, Allies G, Maity P, Wilms C, Wlaschek M, Scharffetter-Kochanek K. (2015). Histone H2A deubiquitinase 2A-DUB/Mysm1 regulates critical checkpoints of early T cell development and lymphopoiesis via p53-dependent and –independent mechanisms. Cell Death Differ 22:1451-62

 

Tauc HM*, Tasdogan A*, Pandur P. (2014). Isolating intestinal stem cells from adult Drosophila midguts by FACS to study stem cell behavior during aging. J Vis Exp 94

*contributed equally to this work

 

Gatzka M, Hainzl A, Peters T, Singh K, Tasdogan A, Wlaschek M, Scharffetter-Kochanek K. (2013). Reduction of CD18 promotes expansion of inflammatory γδ T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis. J Immunol 191:5477-882.

 

Luche H, Nageswara Rao T, Kumar S, Tasdogan A, Beckel F, Blum C, Martins VC, Rodewald HR, Fehling HJ. (2013) In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis. J Exp Med 210:699-714.