Publications
Selected publications
KDM5B predicts temozolomide-resistant subclones in glioblastoma
Ullrich, Vivien; Ertmer, Sarah; Baginska, Anna; Dorsch, Madeleine; Gull, Hanah H.; Cima, Igor; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Meyer, Loona; Dujardin, Philip; Kebir, Sied; Glas, Martin; Blau, Tobias; Keyvani, Kathy; Rauschenbach, Laurèl; Sure, Ulrich; Roesch, Alexander; Grüner, Barbara M.; Scheffler, Björn
In: iScience Vol. 27 (2024) Nr. 1, 108596
A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500
Reduced Staphylococcus Abundance Characterizes the Lesional Microbiome of Actinic Keratosis Patients after Field-Directed Therapies
Kehrmann J, Koch F, Zumdick S, Höwner A, Best L, Masshöfer L, Scharfenberg S, Zeschnigk M, Becker JC, Schadendorf D, Buer J, Roesch A.Microbiol Spectr. 2023 Jun 15;11(3):e0440122. doi: 10.1128/spectrum.04401-22. Epub 2023 May 22.PMID: 37212689 Free PMC article.
Adjuvant treatment and outcome of stage III melanoma patients : Results of a multicenter real-world German Dermatologic Cooperative Oncology Group (DeCOG) study
Lodde, Georg; Hassel, Jessica; Wulfken, Lena M.; Meier, Friedegund; Mohr, Peter; Kähler, Katharina; Hauschild, Axel; Schilling, Bastian; Loquai, Carmen; Berking, Carola; Hüning, Svea; Eckardt, Julia; Gutzmer, Ralf; Reinhardt, Lydia; Glutsch, Valerie; Nikfarjam, Ulrike; Erdmann, Michael; Beckmann, Catharina L.; Stang, Andreas; Kowall, Bernd; Galetzka, Wolfgang; Rösch, Alexander; Ugurel, Selma; Zimmer, Lisa; Schadendorf, Dirk; Forschner, Andrea; Livingstone, Elisabeth
In: European Journal of Cancer (EJC) Vol. 191 (2023) 112957
Immunotherapy responses of patients with metastatic melanoma are linked to IL-17 signalin
Varaljai, Renata; Rösch, Alexander
In: Nature Cancer Vol. 4 (2023) Nr. 9, pp. 1224 - 1225
Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
In: Nature Cancer Vol. 4 (2023) Nr. 9, pp. 1292 - 1308
Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype
Albrecht, Lea Jessica; Höwner, Anna; Griewank, Klaus; Lueong, Smiths S.; von Neuhoff, Nils; Horn, Peter; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Horn, Susanne; Siveke, Jens; Schadendorf, Dirk; Váraljai, Renáta; Rösch, Alexander
In: Clinical and Translational Medicine Vol. 12 (2022) Nr. 11, e1090
Persister state-directed transitioning and vulnerability in melanoma
Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
In: Nature Communications
Vol. 13 (2022) Nr. 1, 3055
Brase JC, Walter RFH, Savchenko A, Gusenleitner D, Garrett J, Schimming TT, Váraljai R, Castelletti D, Kim JY, Dakappagari NK, Schultz K, Robert C, Long GV, Nathan PD, Ribas A, Flaherty KT, Karaszewska B, Schachter J, Sucker A, Schmid KW, Zimmer L, Livingstone E, Gasal E, Schadendorf D, Roesch A.
Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib. Clin Cancer Res. 2021 Jun 9:clincanres.3586.2020. doi: 10.1158/1078-0432.CCR-20-3586. Epub ahead of print. PMID: 34108180.
Zaremba A, Philip M, Hassel JC, Glutsch V, Fiocco Z, Loquai C, Rafei-Shamsabadi D, Gutzmer R, Utikal J, Haferkamp S, Reinhardt L, Kähler KC, Weishaupt C, Moreira A, Thoms KM, Wilhelm T, Pföhler C, Roesch A, Ugurel S, Zimmer L, Stadtler N, Sucker A, Kiecker F, Heinzerling L, Meier F, Meiss F, Schlaak M, Schilling B, Horn S, Schadendorf D, Livingstone E.
Clinical characteristics and therapy response in unresectable melanoma patients stage IIIB-IIID with in-transit and satellite metastases. Eur J Cancer. 2021 Jun 5;152:139-154. doi: 10.1016/j.ejca.2021.04.032. Epub ahead of print. PMID: 34102453.
Chorti E, Kebir S, Ahmed MS, Keyvani K, Umutlu L, Kanaki T, Zaremba A, Reinboldt-Jockenhoefer F, Knispel S, Gratsias E, Roesch A, Ugurel S, Scheffler B, Schadendorf D, Livingstone E, Meier F, Glas M, Zimmer L.
Leptomeningeal disease from melanoma-Poor prognosis despite new therapeutic modalities. Eur J Cancer. 2021 May;148:395-404. doi: 10.1016/j.ejca.2021.02.016. Epub 2021 Mar 28. PMID: 33789203.
Lodde G, Forschner A, Hassel J, Wulfken LM, Meier F, Mohr P, Kähler K, Schilling B, Loquai C, Berking C, Hüning S, Schatton K, Gebhardt C, Eckardt J, Gutzmer R, Reinhardt L, Glutsch V, Nikfarjam U, Erdmann M, Stang A, Kowall B, Roesch A, Ugurel S, Zimmer L, Schadendorf D, Livingstone E.
Factors Influencing the Adjuvant Therapy Decision: Results of a Real-World Multicenter Data Analysis of 904 Melanoma Patients. Cancers (Basel). 2021 May 12;13(10):2319. doi: 10.3390/cancers13102319. PMID: 34065995; PMCID: PMC8151445.
Harbers FN, Thier B, Stupia S, Zhu S, Schwamborn M, Peller V, Chauvistré H, Crivello P, Fleischhauer K, Roesch A, Sucker A, Schadendorf D, Chen Y, Paschen A, Zhao F.
Melanoma differentiation trajectories determine sensitivity towards pre-existing CD8+ tumor-infiltrating lymphocytes. J Invest Dermatol. 2021 Mar 30:S0022-202X(21)01124-6. doi: 10.1016/j.jid.2021.03.013. Epub ahead of print. PMID: 33798535.
Váraljai R, Horn S, Sucker A, Piercianek D, Schmitt V, Carpinteiro A, Becker KA, Reifenberger J, Roesch A, Felsberg J, Reifenberger G, Sure U, Schadendorf D, Helfrich I.
Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma. Cancers (Basel). 2021 Feb 10;13(4):731. doi: 10.3390/cancers13040731. PMID: 33578810; PMCID: PMC7916600.
Shannan B, Matschke J, Chauvistré H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Varaljai R, Hoewner A, Horn S, Klode J, Stuschke M, Scheffler B, Schadendorf D, Jendrossek V, Roesch A.
Sequence-dependent crossresistanceof combined radiotherapy plus BRAFV600E-inhibition in melanoma. Submitted
Vogel F, Bordag N, Zügner E3, Trajkovic-Arsic M, Chauvistré H, Shannan B, Horn S, Váraljai R, Magnes C, Siveke J, Schadendorf D, Roesch A.
Targeting the H3K4 demethylase KDM5B/JARID1B affects the metabolic landscape and malignant phenotype of melanoma cells. submitted
Chauvistré H, Daignault SM, Shannan B, Picard D, Krepler C, Ju RJ, Vogel F, Kaschani F, Ninck S, Sechi A, Keminer O, Varaljai R, Stehbens SJ, Löffek S, Liu Q, Yin X, Jeyakumar K, Gul S, Rahmann S, Horn S, Ehrmann M, Paschen A, Helfrich I, Remke M, Rauh D, Kaiser M, Haass NK, Herlyn M, Schadendorf D, Roesch A.
Overcoming tumor plasticity by chemically enforced phenotype homogenization as a new therapeutic strategy in melanoma. submitted
Váraljai R, Wistuba-Hamprecht K, Seremet T, Diaz JMS, Nsengimana J, Sucker A, Placke JM, Horn PA, Neuhoff N, Shannan B, Chauvistré H, Vogel F, Horn S, Becker JC, Newton-Bishop J, Stang A, Neyns B, Weide B, Schadendorf D, Roesch A.
Application of circulating cell-free tumor DNA profiles to therapeutic monitoring and outcome prediction in genetically heterogeneous metastatic melanoma. submitted
Schadendorf D, Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S.
Lancet Seminar – Melanoma. The Lancet, accepted for publication
Kunz M, Löffler-Wirth H, Dannemann M, Willscher E, Doose G, Kelso J, Kottek T, Nickel B, Hopp L, Landsberg J, Hoffmann S, Tüting T, Zigrino P, Mauch C, Utikal J, Ziemer M, Schulze HJ, Hölzel M, Roesch A, Kneitz S, Meierjohann S, Bosserhoff A, Binder H, Schartl M.
RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas. Oncogene. 2018 Jul 11. doi: 10.1038/s41388-018-0385-y. [Epub ahead of print]
Cosgarea I, Ugurel S, Sucker A, Livingstone E, Zimmer L, Ziemer M, Utikal J, Morh P, Pfeiffer C, Pföhler C, Hillen U, Horn S, Schadendorf D, Griewank KG, Roesch A.
Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations. Oncotarget. 2017 Jun 20;8(25):40683-40692
Krepler C, Sproesser K, Brafford P, Beqiri M, Garman B, Xiao M, Shannan B, Watters A, Perego M, Zhang G, Vultur A, Yin X, Liu Q, Anastopoulos IN, Wubbenhorst B, Wilson MA, Xu W, Karakousis G, Feldman M, Xu X, Amaravadi R, Gangadhar TC, Elder DE, Haydu LE, Wargo JA, Davies MA, Lu Y, Mills GB, Frederick DT, Barzily-Rokni M, Flaherty KT, Hoon DS, Guarino M, Bennett JJ, Ryan RW, Petrelli NJ, Shields CL, Terai M, Sato T, Aplin AE, Roesch A, Darr D, Angus S, Kumar R, Halilovic E, Caponigro G, Jeay S, Wuerthner J, Walter A, Ocker M, Boxer MB, Schuchter L, Nathanson KL, Herlyn M.
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma. Cell Rep. 2017 Nov 14;21(7):1953-1967
Behera R, Kaur A, Webster MR, Kim S, Ndoye A, Kugel CH, Alicea GM, Wang JX, Ghosh K, Cheng PF, Lisanti S, Marchbank K, Dang V, Levesque MP, Dummer R, Xu X, Heryn M, Aplin AE, Roesch A, Caino MC, Altieri DC, Weeraratna AT.
Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017 Feb 23.
Roesch A, Paschen A, Landsberg J, Helfrich I, Becker JC, Schadendorf D.
Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma. Eur J Cancer. 2016 May;59:109-12.
Facompre ND, Harmeyer KM, Sole X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ramaswamy S, Basu D.
JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers. Cancer Res. 2016 Sep 15;76(18):5538-49.
Zhao F, Sucker A, Horn S, Heeke C, Bielefeld N, Schrörs B, Bicker A, Lindemann M, Roesch A, Gaudernack G, Stiller M, Becker JC, Lennerz V, Wölfel T, Schadendorf D, Griewank K, Paschen A.
Melanoma lesions independantly acquire T-cell resistance during metastatic latency. Cancer Res. 2016 Aug 1;76(15):4347-58.
Roesch A.
Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanoma. Oncogene. 2015 Jun 4;34(23):2951-7.
Schadendorf D, Fisher DE, Garbe C, Gershenwald JE, Grob JJ, Halpern A, Herlyn M, Marchetti MA, McArthur G, Ribas A, Roesch A, Hauschild A.
Melanoma. Nat Rev Dis Primers. 2015 Apr 23;1:15003
Cierlitza M, Chauvistré H, Bogeski I, Hauschild A, Herlyn M, Vogt T, Schadendorf D, Roesch A.
Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations. Exp Dermatol. 2015 Feb;24(2):155-7
Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J.
Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med. 2015 Dec 9;7(317):317ra199.
Stanisz S, Saul S, Hoth M, Vogt T, Roesch A, Bogeski I.
Orai1 calcium channels regulate melanoma growth and invasion. Pigment Cell Melanoma Res. 2014 May;27(3):442-53.
Stanisz H, Saul S, Müller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I.
Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Pigment Cell Melanoma Res. 2014 May;27(3):442-53.
Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M.
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1Bhigh cells. Cancer Cell. 2013 Jun 10;23(6):811-25.
Niessner H, Forschner A, Klumpp B, Honegger JB, Witte M, Bornemann A, Dummer R, Adam A, Bauer J, Tabatabai G, Flaherty K, Sinnberg T, Beck D, Leiter U, Mauch C, Roesch A, Weide B, Eigentler T, Schadendorf D, Garbe C, Kulms D, Quintanilla-Martinez L, and Meier F.
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases. Cancer Med. 2013 Feb;2(1):76-85.
Magnitsky S, Roesch A, Herlyn M, Glickson JD. (2011)
In vivo and ex vivo MR Imaging of slowly cycling melanoma cells. Magn Reson Med. 2011 Nov;66(5):1362-73.
Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Gimotty P, Vogt T, Herlyn M.
The dynamic expression of JARID1B in a subpopulation of melanoma is required for continuous tumor growth. Cell. 2010 May 14;141(4):583-94.
Fukunaga-Kalabis M, Martinez G, Nguyen TK, Kim D, Santiago-Walker A, Roesch A, Herlyn M.
Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene. 2010 Nov 18;29(46):6115-24.
Roesch A, Mueller AM, Stempfl T, Moehle C, Landthaler M, Vogt T.
RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. Int J Cancer. 2008 Mar 1;122(5):1047-57.
Roesch A, Becker B, Schneider-Brachert W, Landthaler M, Vogt T.
Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor suppressive functions in highly metastatic melanoma cells. J Invest Dermatol. 2006 Aug;126(8):1850-9.
Roesch A, Becker B, Meyer S, Hafner C, Wild PJ, Landthaler M, Vogt T.
Retinoblastoma Binding Protein 2-Homolog 1: A retinoblastoma binding protein downregulated in malignant melanomas. Mod Pathol. 2005 Sep;18(9):1249-57.
Roesch A, Becker B, Meyer S, Hafner C, Wild PJ, Landthaler M, Vogt T.
Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma. Mod Pathol. 2005 Apr;18(4):565-72.